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Disoprofol and fentanyl for total intravenous anaesthesia
Author(s) -
MAJOR E.,
VERNIQUET A. J. W.,
YATE P. M.,
WADDELL T. K.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb01224.x
Subject(s) - medicine , fentanyl , anesthesia , microgram , breathing , surgery , biochemistry , chemistry , in vitro
Summary Ninety patients undergoing a variety of surgical procedures were anaesthetised with a disoprofol infusion and increments of fentanyl. The first 40 patients constituted a preliminary dose finding study and the subsequent 50 patients a dose comparison study. The second 50 patients were alternately allocated to receive a maintenance infusion of disoprofol 150 or 200 μg/kg/minute. Fentanyl (1 μg/kg) at induction was followed by further small increments when indicated. Maintenance dosage of 200 μg/kg/minute provided good operating conditions and rapid uncomplicated recovery in spontaneously breathing patients, while 150 μg/kg/minute proved inadequate to prevent patient movement.