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Prostaglandin E 1 as a hypotensive drug during general anaesthesia
Author(s) -
GOTO F.,
OTANI E.,
KATO S.,
FUJITA T.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb01222.x
Subject(s) - medicine , anesthesia , blood pressure , prostaglandin e1 , heart rate
Summary Hypotension induced by prostaglandin E 1 (PGE 1 ) infusion (100–150 ng/kg/minute) during halothane anaesthesia to reduce operative blood loss during mastectomy was investigated. PGE 1 decreased systolic arterial pressure approximately 34% from pre‐administration values. The duration of induced hypotension was about 75 minutes. When the infusion was stopped, blood pressure returned to within 15% of the control with 15 minutes. Heart rate did not change significantly during PGE 1 infusion; the pre‐ejection period and left ventricular ejection period were shortened. Renal function during the hypotensive period was well maintained. Blood loss during surgery was significantly decreased. These findings suggest that PGE 1 can be used safely to control arterial pressure during surgery.