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Cimetidine as an oral antacid before elective Caesarean section
Author(s) -
JOHNSTON J. R.,
McCAUGHEY W.,
MOORK J.,
DUNDEE J. W.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb00989.x
Subject(s) - antacid , cimetidine , medicine , elective caesarean section , caesarean section , anesthesia , antagonist , duodenal ulcer , elective cesarean section , pregnancy , receptor , biology , genetics
Summary The H 2 ‐receptor antagonist cimetidine was used as a pre‐operative antacid in 64 women scheduled for elective Caesarean section. All were given cimetidine 400 mg 90–215 minutes before induction, with 20 of them having an extra 400 mg dose the previous night. The intragastric pH at induction of anaesthesia was reliably above 2.5 if the treatment was given 90 150 minutes beforehand. The volume of gastric contents was reduced when compared with a control series of women receiving either no pre‐operative antacid or 30 ml magnesium trisilicate mixture BPC. No adverse effects on mothers or infants were detected.