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The fibrinolytic effects of anaesthesia
Author(s) -
SIMPSON P. J.,
RADFORD SHEILA G.,
FORSTER S. J.,
COOPER GRISELDA M.,
HUGHES A. O.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb00985.x
Subject(s) - medicine , fibrinolysis , anesthesia , fibrin , fibrinogen , halothane , general anaesthesia , immunology
Summary The fibrinolytic effects of six different anaesthetic agents were studied in 36 patients undergoing abdominal hysterectomy. Fibrinolytic activity was measured by dilute whole blood and euglobulin clotlysis times. Concentrations of plasminogen, fibrinogen and fibrin degradation products were also determined. Significant enhancement of fibrinolytic activity, measured as a decrease in clotlysis time, was seen during anaesthesia and surgery with all agents studied. Halothane produced the least effect and the greatest increase in fibrinolytic activity was seen during trichloroethylene anaesthesia. Lumbar extradural anaesthesia also consistently produced enhancement of fibrinolysis. The reasons for these results and their clinical implications are discussed.