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Dose‐response relationship for disoprofol (ICI 35868; Diprivan)
Author(s) -
KAY B.,
STEPHENSON D.K.
Publication year - 1981
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1981.tb08858.x
Subject(s) - medicine , anesthesia , loading dose , incidence (geometry) , sleep (system call) , physics , computer science , optics , operating system
Summary The duration of sleep following intravenous administration of three doses of disoprofol (1, 2 and 3 mg/kg) was compared with that following methohexitone 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side‐effects were dose‐related for both drugs, but the incidence was significantly less following disoprofol than methohexitone 2 mg/kg. The most frequent side‐effects were pain on injection, myoclonia and hiccup. Studies of blood concentrations of disoprofol show that the profile is dose‐independent and conforms to a two‐compartment model with a very short distribution phase (about 2 minutes) and short elimination phase (about 70 minutes). Waking blood levels gave no indication of acute tolerance. Disoprofol would appear to be particularly useful for induction of a short period of sleep using a small dose given quickly, or for maintenance of sleep by continuous infusion.