Premium
Methylprednisolone prior to cardiopulmonary bypass
Author(s) -
THOMPSON M.A.,
BROADBENT M.P.
Publication year - 1980
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1980.tb05115.x
Subject(s) - medicine , cardiopulmonary bypass , methylprednisolone , anesthesia , significant difference , saline , radioimmunoassay , oxygen , chemistry , organic chemistry
Summary Patients undergoing cardiopulmonary bypass were randomly allocated to receive methylprednisolone 30 mg/kg in a single dose prior to bypass, or to a control group receiving saline. The effect of this treatment on 2,3‐DPG and oxygen delivery to the tissues was determined. There was no difference between the groups in 2,3‐DPG levels, P50 or oxygen availability, but the methylprednisolone group showed a highly significant difference in oxygen consumption immediately following cardiopulmonary bypass (p < 0·001) and a significant difference in serum phosphate levels in the immediate postoperative period (p < 0·05). Methylprednisolone levels were measured by radioimmunoassay, and these showed a rapid decline in the 4 hours following administration.