Premium
Prolonged neuromuscular blockade following trimetaphan infusion
Author(s) -
NAKAMURA KUMI,
KOIDE MASAHARU,
IMANAGA TERUAKI,
OGASAWARA HIROKO,
TAKAHASHI MAKIKO,
YOSHIKAWA MASATO
Publication year - 1980
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1980.tb05079.x
Subject(s) - cholinesterase , neuromuscular blockade , medicine , anesthesia , neuromuscular transmission , acetylcholine , blockade , pharmacology , receptor
Summary This is a case report with postoperative prolonged neuromuscular blockade of 17 hours duration suspected to be caused by trimetaphan. Inhibitory action of trimetaphan to true cholinesterase (human red cell cholinesterase) was estimated in vitro, and it is concluded that this action is too weak to cause neuromuscular disturbances by acetylcholine excess in clinical doses. Trimetaphan is considered to have a neuromuscular blocking action of a non‐depolarising type.