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Haemodynamic changes following buprenorphine and morphine
Author(s) -
SCOTT DAVID H. T.,
ARTHUR G. RICHARD,
SCOTT D. BRUCE
Publication year - 1980
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1980.tb04993.x
Subject(s) - medicine , hemodynamics , anesthesia , buprenorphine , blood pressure , cardiac output , mean arterial pressure , contractility , morphine , crossover study , heart rate , cardiology , opioid , receptor , alternative medicine , pathology , placebo
Summary Twenty‐five women were investigated on the day after lower abdominal surgery in a single‐blind non‐crossover trial to assess and compare the haemodynamic effects of intravenous injections of buprenorphine 0·3 mg and morphine 7·5 mg. Arterial blood pressure was measured by sphygmomanometry and cardiac output by thoracic impedance cardiograph. Arterial blood pressure was significantly reduced following both drugs (p < 0·05), although the mean decrease in systolic arterial pressure was less than 8 mmHg. However, in one patient in each group the decrease was more than 20 mmHg. Cardiac output decreased but the mean reduction was less than 5%. The greatest individual decreases were 21% after buprenorphine and30% after morphine. Myocardial contractility, assessed by systolic time indices, did not appear to change. There were no consistent differences in the haemodynamic effects of the two drugs.