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Respiratory effects of Minaxolone
Author(s) -
Puchihewa V. G.,
Whitwam J. G.,
Morgan M.,
Lumley Jean
Publication year - 1980
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1980.tb03863.x
Subject(s) - medicine , premedication , anesthesia , narcotic , atropine , respiratory system , respiratory minute volume , significant difference , respiratory rate , heart rate , blood pressure
Summary The respiratory effects of induction of anaesthesia with Minaxolone 0·4 mg/kg were studied following premediction with either atropine alone, lorazepam and atropine or papaveretum and hyoscine. There was no significant difference in the incidence of apnoea in the three groups, Those who received non‐narcotic premedication showed a significant increase in respiratory rate, but the minute volumes in these patients did not differ significantly from control values in the third minute after injection of minaxolone. In those who received papaveretum and hyoscine, there was no change in respiratory rate and a highly significant reduction in minute volume.