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Mixed neuromuscular block
Author(s) -
ROUSE JANE M.,
BEVAN D.R.
Publication year - 1979
Publication title -
anaesthesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1979.tb06358.x
Subject(s) - medicine , anesthesia , paralysis , neuromuscular blockade , block (permutation group theory) , spontaneous recovery , muscle relaxation , stimulation , surgery , geometry , mathematics
Suxamethonium was administered to patients during recovery from non-depolarising muscle relaxation. The effect of suxamethonium varied depending upon the degree of recovery from the non-depolarising block when it was administered. Early in recovery suxamethonium produced reversal of the non-depolarising block without paralysis whereas when administered later, initial recovery of the non-depolarising block was followed by paralysis. If administered after 50% recovery the predominant effect was paralysis without initial recovery. Assessment of neuromuscular blockade with train-of-four stimulation showed that the paralysis produced by suxamethonium under these circumstances, had depolarising and non-depolarising features.