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The effects of ketamine on the canine coronary circulation
Author(s) -
SMITH G.,
THORBURN J.,
VANCE J.P.,
BROWN D.M.
Publication year - 1979
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1979.tb06341.x
Subject(s) - medicine , ketamine , anesthesia , hemodynamics , cardiac output , bolus (digestion) , blood pressure , coronary circulation , stroke volume , blood flow , cardiology , heart rate
Systemic and coronary haemodynamic measurements have been made in six healthy greyhounds anaesthetized with trichloroethylene. The administration of ketamine in bolus doses of 5 mg/kg, 10 mg/kg and 5 mg/kg followed by an infusion 0.1 mg/kg/min was found to be accompanied by a decrease in arterial pressure and an increase in cardiac output produced by an increase (84%) in stroke volume. Coronary blood flow increased greatly as did myocardial oxygen consumption and there was no change in myocardial oxygen extraction.