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Potential hazard of methylene blue
Author(s) -
WHITWAM J.G.,
TAYLOR A.R.,
WHITE J.M.
Publication year - 1979
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1979.tb06275.x
Subject(s) - methylene blue , medicine , methemoglobin , methylene , hexose , biochemistry , hemoglobin , enzyme , medicinal chemistry , chemistry , photocatalysis , catalysis
The administration of methylene blue to assist the identification of insulin secreting pancreatic adenomata, during surgery in a patient with normal haemoglobin and red cells, was associated with an increase in the methaemoglobin concentration from 0.6% to 7.1%. In patients with unstable haemoglobins or abnormalities of the hexose monophosphate pathway the administration of large amounts of methylene blue is potentially dangerous.