Propranolol in thyrotoxicosis. Cardiovascular changes during thyroidectomy in patients pre‐treated with propranolol | Zendy

Trench A.J. | Zendy; Buckley F.P. | Zendy; Drummond G.B. | Zendy; Arthur G.R. | Zendy; Scott D.B. | Zendy

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Propranolol in thyrotoxicosis. Cardiovascular changes during thyroidectomy in patients pre‐treated with propranolol

Author(s) -

Trench A.J.,

Buckley F.P.,

Drummond G.B.,

Arthur G.R.,

Scott D.B.

Publication year - 1978

Publication title -

anaesthesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.839

H-Index - 117

eISSN - 1365-2044

pISSN - 0003-2409

DOI - 10.1111/j.1365-2044.1978.tb08392.x

Subject(s) - medicine , propranolol , cardiac output , anesthesia , thyroidectomy , stroke volume , heart rate , blood pressure , stroke (engine) , cardiology , cardiac surgery , thyroid , surgery , hemodynamics , mechanical engineering , engineering

The cardiovascular changes during anaesthesia and thyroidectomy have been studied in seven thyrotoxic patients prepared with propranolol. The heart rate and cardiac rhythm remained very stable throughout surgery. A 20% increase in mean arterial pressure occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgery, reaching a maximum of 21% during ligation of the thyroid vessels and returning to pre-operative values by the end of surgery. The fall in cardiac output was accompanied by raised central venous pressure and raised total peripheral resistance.

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