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Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam
Author(s) -
Graham C. W.,
Pagano R. R.,
Conner J. T.
Publication year - 1978
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1978.tb08348.x
Subject(s) - medicine , lorazepam , diazepam , thrombophlebitis , anesthesia , surgery , thrombosis
Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis. This was improved when diazepam, 10 mg, was diluted to 20-40 ml with intravenous solution. In contrast, lorazepam appeared to have minimal irritative or injurious effects on veins whether undiluted or diluted. In view of these results and clinical studies reporting a higher patient acceptance of lorazepam than diazepam, lorazepam may be a superior drug for use in anaesthesia.