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Estimation of plasma lorazepam by gas‐liquid chromatography and a benzene extraction
Author(s) -
HOWARD P.J.,
LILBURN J.K.,
DUNDEE J.W.,
TONER W.,
McILROY P.D.A.
Publication year - 1977
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1977.tb10078.x
Subject(s) - lorazepam , chromatography , medicine , flunitrazepam , extraction (chemistry) , benzene , gas chromatography , plasma , anesthesia , chemistry , organic chemistry , benzodiazepine , physics , receptor , quantum mechanics
Plasma lorazepam can be easily and reliably estimated using a simple single stage benzene extraction and gas-lizuid chromatography with flunitrazepam as the internal standard. Reproducible results within the clinical range of plasma levels were obtained. This method permits the extraction and chromatographing of 40 samples in approximately 7 1/2 hours.