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Adrenal tumour secreting vasoactive intestinal peptide and noradrenaline
Author(s) -
TAYLOR A.R.,
CHULAJATA D.,
JONES D.H.,
WHITWAM J.G.
Publication year - 1977
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1977.tb09965.x
Subject(s) - vasoactive intestinal peptide , medicine , vasoactive , metaraminol , ganglioneuroblastoma , norepinephrine , endocrinology , neuroendocrine tumour , neuropeptide , blood pressure , receptor , neuroblastoma , dopamine , ganglioneuroma , biology , cell culture , genetics
A patient with a ganglioneuroblastoma secreting both noradrenaline and vasoactive intestinal peptide is described. Their vasoactive effects are antagonistic and pre-operatively the patient was normotensive. Manipulation of the tumour provoked hypertension and after excision marked hypotension occurred which responded to the administration of metaraminol and blood. This case emphasises the need for thorough investigation of patients with amine or peptide-secreting tumours which have atypical features.