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The administration of metoclopramide with atropine A drug interaction effect on the gastro–oesophageal sphincter in man
Author(s) -
BROCKUTNE J. G.,
RUBIN J.,
DOWNING J. W.,
DIMOPOULOS G. E.,
MOSHAL M. G.,
NAICKER M.
Publication year - 1976
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1976.tb11970.x
Subject(s) - medicine , metoclopramide , atropine , gastro , anesthesia , drug , sphincter , parasympatholytic , pharmacology , surgery , reflux , muscarinic acetylcholine receptor , receptor , disease , vomiting
The effects of intravenous atropine 0-6 mg alone, metoclopramide (Maxolon) 10mg alone and atropine 0-6 mg and metoclopramide 10 mg in combination, on the lower oesophageal sphincter (LOS) were studied in three groups of normal human volunteers. Atropine decreased the LOS pressure by an average of 8 cm H2O (P less than 0-001), whereas metoclopramide increased the LOS pressure by a mean of 29 cmH2O compared to basal values (P less than 0-001). In contrast, no change in sphincter tone was noted following injection of atropine-metaclopramide mixture. These findings are relevant to the pre-operative preparation of patients presenting for emergency anaesthesia, since gasgro-oesophageal reflux and pulmonary aspiration of acid gastric content continues to be a significant cause of morbidity and mortality.