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Anticholinergic actions of steroid muscle relaxants
Author(s) -
BADEN J. M.
Publication year - 1976
Publication title -
anaesthesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1976.tb11794.x
Subject(s) - medicine , chronotropic , bradycardia , anticholinergic , acetylcholine , pancuronium bromide , neostigmine , atropine , anesthesia , neuromuscular blockade , pharmacology , agonist , heart rate , receptor , blood pressure
The chronotropic effects of two new steroid muscle relaxants have been investigated. Each was compared individually with pancuronium bromide, using acetylcholine as an agonist on the isolated perfused rabbit heart. One of the drugs. Organon 6368, was very similar to pancuronium in its degree of antagonism to the bradycardia produced by acetylcholine and may therefore be a useful drug clinically. Dacuronium, on the other hand, would appear to have marked chronotropic effects at dose levels needed for adequate neuromuscular blockade and thus may be less useful.