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Lorazepam as a premedicant for day‐case surgery: an assessment
Author(s) -
Loach A.,
Fisher A.
Publication year - 1975
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1975.tb00903.x
Subject(s) - medicine , lorazepam , sedation , premedication , anesthesia , nitrazepam , sedative , placebo , minor surgery , diazepam , surgery , alternative medicine , pathology
The sedative effect of 2 mg of lorazepam was assessed in eleven patients undergoing minor "day case" surgery and the results compared with a control group of eleven patients receiving a placebo. Sedation was assessed by a scoring method and quantified in terms of change in plasma cortisol levels. The results indicate that 2 mg of oral lorazepam produces good sedation (superior to nitrazepam in terms of plasma cortisol reduction) and has a postoperative anti-emetic effect but its prolonged duration of action makes it unsuitable for patients returning home within 8 hours of premedication.