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The cardiovascular effects of dantrolene sodium in dogs
Author(s) -
ELLIS RICHARD H.,
SIMPSON PETER,
TATHAM PETER,
LEIGHTON MONICA,
WILLIAMS JOHN
Publication year - 1975
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1975.tb00862.x
Subject(s) - medicine , dantrolene sodium , dantrolene , anesthesia , saline , heart rate , blood pressure , sodium , cardiac output , hemodynamics , calcium , chemistry , organic chemistry
The effects of the intravenous infusion of dantrolene sodium and of equal volumes of normal saline on arterial pressure, central venous pressure, heart rate and cardiac output have been investigated in healthy, anaesthetised dogs. The infusion of dantrolene in the manner and dose found to be effective by other workers in pigs-8 for the treatment of anaesthetic induced malignant hyperpyrexia, produced changes which differ little from those observed after the infusion of a similar quantity of saline. These results are discussed.