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Estimation of plasma diazepam
Author(s) -
GAMBLE J. A. S.,
ASSAF R. A. E.,
MACKAY J. S.,
KENNEDY MARGARET S.,
HOWARD P. J.
Publication year - 1975
Publication title -
anaesthesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1975.tb00827.x
Subject(s) - medicine , diazepam , griseofulvin , plasma , extraction (chemistry) , chromatography , plasma levels , benzene , anesthesia , plasma concentration , pharmacology , pathology , organic chemistry , chemistry , physics , quantum mechanics
Plasma diazepam can be reliably estimated using a simple benzene extraction and gas-liquid chromatography with griseofulvin as internal standard. This gives reproducible results within the clinical range of plasma levels. Storage at minus 20 degrees C is recommended but is not essential for the 1st week.