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Human placental transfer of AH 8165
Author(s) -
BLOGG C. E.,
SIMPSON B. R.,
TYERS M. B.,
MARTIN L. E.,
BELL J. A.
Publication year - 1975
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1975.tb00790.x
Subject(s) - medicine , placenta , caesarean section , fetus , vein , anesthesia , hysterectomy , venous blood , obstetrics , umbilical vein , pregnancy , surgery , in vitro , genetics , chemistry , biology , biochemistry
The human placental transfer of AH8165 (0times50times9 mg/kg) was studied in ten patients undergoing elective Caesarean section. There was no adverse effect on foetal movement attributable to placental transfer of the neuromuscular blocking drug. Bioassay of umbilical vein blood indicated that little AH8165 crossed the placenta. Studies using 3HAH8165 in two patients undergoing termination hysterectomy demonstrated transfer of only minute amounts of radioactivity to the foetus.