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Neuroleptic malignant syndrome: Successful treatment with dantrolene and bromocriptine
Author(s) -
Granato Jerome E.,
Stern Barney J.,
Ringel Alan,
Karim Amin H.,
Krumholz Allan,
Coyle Joseph,
Adler Sam
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1111/j.1365-2044.1959.tb01675.x
Subject(s) - dantrolene , bromocriptine , neuroleptic malignant syndrome , medicine , fluphenazine , creatine kinase , anesthesia , malignant hyperthermia , hyperthermia , surgery , prolactin , calcium , hormone , dopamine , haloperidol
A patient with chronic schizophrenia treated with fluphenazine developed neuroleptic malignant syndrome, characterized by fever, obtundation, rigidity, and tremulousness. Hyperthermia and elevated serum creatine kinase were successfully corrected by parenteral treatment with dantrolene. Obtundation, rigidity, and tremulousness responded to high doses of bromocriptine.