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Polyneuropathy in nonmalignant IgM plasma cell dyscrasia: A Morphological study
Author(s) -
Nemni Rafaello,
Galassi Giuliana,
Latov Norman,
Sherman William H.,
Olarte Marcelo R.,
Hays Arthur P.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1111/j.1365-2044.1959.tb01660.x
Subject(s) - plasma cell dyscrasia , pathology , polyneuropathy , medicine , myelin , peripheral neuropathy , pathogenesis , monoclonal , dyscrasia , paraproteinemias , immunology , immunoglobulin m , myelin associated glycoprotein , sural nerve , axon , plasma cell , antibody , monoclonal antibody , immunoglobulin g , anatomy , immunoglobulin light chain , endocrinology , central nervous system , diabetes mellitus
Six patients had peripheral neuropathy and nonmalignant IgM plasma cell dyscrasia. In two of them, immunological studies indicated that the monoclonal immunoglobulin reacted with myelin‐associated glycoprotein, a constituent of peripheral nerve myelin. Sural nerve biopsy specimens from both patients showed morphological signs of primary damage to the myelin sheath. In the other four patients, two of whom had a monoclonal IgMk reactive with chondroitin sulfate C, the axon rather than the myelin sheath was considered the chief site of nerve injury. The morphological findings suggest that the pathogenesis of peripheral neuropathies in IgM plasma cell dyscrasia is heterogeneous. Moreover, the observations are consistent with a pathogenic interaction of the IgM paraprotein with autoantigens in peripheral nerve in some instances.