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Meta‐analysis: the impact of IL 28 B polymorphisms on rapid and sustained virological response in HCV ‐2 and ‐3 patients
Author(s) -
Schreiber J.,
Moreno C.,
Garcia B. Garcia,
Louvet A.,
Trepo E.,
Henrion J.,
Thabut D.,
Mathurin P.,
Deltenre P.
Publication year - 2012
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2012.05197.x
Subject(s) - medicine , gastroenterology , meta analysis , genotype , hepatitis c virus , subgroup analysis , immunology , virus , biology , gene , biochemistry
Summary Background Recent studies suggested that IL 28 B polymorphisms may affect rapid and sustained virological response rates in HCV patients infected with genotype 2 or 3. Aim To assess the role of IL 28 B polymorphisms on the virological response in HCV ‐2 and ‐3 patients. Methods We performed meta‐analysis of studies evaluating the impact of rs12979860 and rs8099917 polymorphisms on rapid and sustained virological response in HCV ‐2 or ‐3 patients. Results Twenty‐three studies involving 3042 patients were included. The first meta‐analysis evaluated the impact of rs12979860 polymorphism and included 1963 patients. When compared with rs12979860 CT / TT patients, CC patients had a higher rapid virological response rate (mean difference: 12.9%, 95% CI : 6.5–19.4%, P < 0.001) and a higher sustained virological response rate (mean difference: 4.9%, 95% CI : 0.1–9.8%, P = 0.046). The second meta‐analysis evaluated the impact of rs8099917 polymorphism and included 2246 patients. When compared with rs8099917 TG / GG patients, TT patients had a higher rapid virological response rate (mean difference: 14.8%, 95% CI : 7.2–22.4%, P < 0.001) and a higher sustained virological response rate (mean difference: 5.5%, 95% CI : 0.4–10.6%, P = 0.033). When considering only patients treated for 24 weeks, results were unchanged. No potential sources of between‐study heterogeneity were identified. Conclusions Favourable IL 28 B polymorphisms are associated with higher rapid and sustained virological response rates in HCV ‐2 and ‐3 patients. However, as the impact on a sustained response is very limited, it is unlikely that IL 28 B polymorphisms provide additional predictive value when considering other predictors of a sustained response.