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Gastrointestinal symptoms before and during menses in women with IBD
Author(s) -
Bernstein M. T.,
Graff L. A.,
Targownik L. E.,
Downing K.,
Shafer L. A.,
Rawsthorne P.,
Bernstein C. N.,
Avery L.
Publication year - 2012
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2012.05155.x
Subject(s) - medicine , menstrual cycle , ulcerative colitis , cohort , abdominal pain , inflammatory bowel disease , gastroenterology , population , young adult , gynecology , disease , hormone , environmental health
Summary Background It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses. Aim To determine the relationship between gastrointestinal and other symptoms and menses in a population‐based cohort of women with IBD vs. healthy women. Methods Women enrolled in the U niversity of M anitoba IBD R esearch R egistry who were between 18 and 65 years were mailed a survey. A control group of adult women were recruited through out‐patient gynaecology clinics. Participants were asked to consider their menstrual periods in the recent several months and report on symptoms 1–5 days prior to and during the days of their menses. Results There were 151 premenopausal women with C rohn's disease ( CD ), 87 with ulcerative colitis ( UC ) and 156 premenopausal controls. Mean age of menses onset was similar in all three cohorts and the percentage in each group with regular menstrual periods was similar. Premenstrually, abdominal pain was less commonly reported in UC (36.8%) than CD (51%, P = 0.034) and controls (57.6%, P = 0.002). Premenstrually, and during menses diarrhoea was more commonly reported in CD (47.7% and 59.6% respectively) than UC (26.4% P = 0.001 and 42.5%, P = 0.01 respectively) and controls (24.4%, P < 0.0001 and 28.2%, P < 0.0001 respectively). Premenstrually, women with CD (46%) vs. UC (26%) were more likely to report worsening of their IBD symptoms ( P = 0.0007), but there was no difference between CD (47%) and UC (39%) for reporting worsening during menses ( P = 0.24). Conclusions Compared to healthy women, women with IBD had similar symptom experiences premenstrually, except that those with CD were more likely to have increased diarrhoea premenstrually. During menses, women with CD or UC were more likely to experience diarrhoea than healthy controls.