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Control of intra‐oesophageal pH in patients with B arrett's oesophagus on omeprazole‐sodium bicarbonate therapy
Author(s) -
Gerson L. B.,
Mitra S.,
Bleker W. F.,
Yeung P.
Publication year - 2012
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2012.05016.x
Subject(s) - medicine , omeprazole , sodium bicarbonate , supine position , reflux , gastroenterology , proton pump inhibitor , bicarbonate , chemistry , disease
Summary Background Approximately 30–40% of patients with B arrett's oesophagus ( BE ) patients manifest abnormal oesophageal pH profiles despite proton pump inhibitor ( PPI ) therapy. Aim To determine control of oesophageal reflux using B ravo pH monitoring in patients BE on omeprazole‐sodium bicarbonate oral suspension powder ( O me‐ N a B ic) 40 mg twice daily. Methods Initial pH monitoring off PPI for 1 week was performed. All patients underwent repeat pH testing on O me‐ N a B ic administered before breakfast and at bedtime after 21–28 days of therapy depending upon the prior PPI therapy. The goal was to enroll 30 subjects, however, the trial was terminated prematurely when the sponsor lost financing due to a change in business strategy. Results A total of 88 patients responded to the study invitation, 27 patients signed informed consent, and 21 patients underwent pH testing of PPI . A total of 15 patients completed the protocol (13 men, 2 women). Demographic information for patients completing at least one B ravo study included a mean (±s.d.) age 62 ± 9 years; body mass index 31 ± 8 kg/m 2 (range 23–48); mean BE length of 2.6 ± 2 cm; 9 (43%) patients with long segment BE . All (100%) patients demonstrated normalisation of supine pH on both days of O me‐ N a B ic therapy. One patient (6%) demonstrated abnormal upright reflux on the second day of monitoring on O me‐ N a B ic therapy; all the other patients demonstrated normal pH scores on therapy. Conclusions Administration of twice daily O me‐ N a B ic demonstrated control of nocturnal oesophageal reflux in 100% of patients with Barrett's oesophagus, and complete control of oesophageal pH during 97% of the 24‐h recording periods.