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Functional dyspepsia impairs quality of life in the adult population
Author(s) -
Aro P.,
Talley N. J.,
Agréus L.,
Johansson S.E.,
BollingSternevald E.,
Storskrubb T.,
Ronkainen J.
Publication year - 2011
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2011.04640.x
Subject(s) - irritable bowel syndrome , quality of life (healthcare) , medicine , vitality , population , epigastric pain , distress , sf 36 , abdominal pain , physical therapy , gastroenterology , anxiety , psychiatry , clinical psychology , health related quality of life , disease , philosophy , nursing , theology , environmental health , vomiting
Aliment Pharmacol Ther 2011; 33: 1215–1224 Summary Background Data on the impact of functional dyspepsia on health‐related quality of life in the general adult population are scarce. Aim To explore the impact of functional dyspepsia applying the Rome III definition on health‐related quality of life in the general population. Method A random sample of an adult Swedish population ( n = 1001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form‐36 (SF‐36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy. Results Two hundred and two (20%) individuals reported uninvestigated dyspepsia (UID), 157 (16%) functional dyspepsia (FD), 52 (5%) epigastric pain syndrome (EPS) and 122 (12%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥ 5 point) and statistically significant impact ( P < 0.05) on health‐related quality of life in all SF‐36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain ( P = 0.002) and General Health ( P = 0.02) while FD overlap with gastro‐oesophageal reflux symptoms (GERS) had a significant impact on Bodily Pain ( P = 0.02) compared with FD without any overlap with IBS or GERS. Conclusion Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health‐related quality of life in the general population. Overlap of functional dyspepsia with irritable bowel syndrome or gastro‐oesophageal reflux symptoms impacts the domain related to bodily pain.