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Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients
Author(s) -
Laine L.,
Curtis S. P.,
Cryer B.,
Kaur A.,
Can C. P.
Publication year - 2010
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2010.04465.x
Subject(s) - medicine , etoricoxib , discontinuation , rheumatoid arthritis , osteoarthritis , diclofenac , aspirin , hazard ratio , proportional hazards model , randomized controlled trial , perforation , gastroenterology , clinical trial , surgery , confidence interval , anesthesia , materials science , alternative medicine , pathology , punching , metallurgy
Aliment Pharmacol Ther 2010; 32: 1240–1248 Summary Background Nonsteroidal anti‐inflammatory drugs (NSAID)‐related GI effects vary based on patient characteristics. Aims To assess risk factors for NSAID‐associated upper GI clinical events and dyspepsia. Methods Patients ≥50 years with osteoarthritis or rheumatoid arthritis were randomized to etoricoxib or diclofenac in a prespecified intent‐to‐treat analysis of three double‐blind randomized trials. Potential risk factors for upper GI clinical events (bleeding, perforation, obstruction, or ulcer), complicated events (perforation, obstruction, bleeding) and discontinuations due to dyspepsia were assessed with Cox proportional hazard models. Results Significant predictors of clinical events and complicated events included age ≥65 years [hazards ratios (HRs) = 2.25 (1.84–2.76), 4.09 (2.82–5.92)], prior event [HRs = 2.57 (1.94–3.39), 3.23 (2.09–5.00)], low‐dose aspirin [HRs = 2.34 (1.87–2.92), 3.41 (2.33–5.00)] and corticosteroid [HRs = 1.85 (1.41–2.43), 2.09 (1.29–3.38)]. Predictors of discontinuation due to dyspepsia included prior dyspepsia [HR = 1.78 (1.44–2.00)], prior event [HR = 1.78 (1.40–2.27)] and age ≥65 years [HR = 1.35 (1.16–1.57)]. Conclusions Assessment for age ≥65 years, prior upper GI clinical events and low‐dose aspirin use are key in identifying patients who should either avoid NSAIDs or employ management strategies to reduce NSAID‐associated upper GI events. Prior dyspepsia or upper GI clinical events and age ≥65 years also predict an increased risk of developing dyspepsia severe enough to necessitate discontinuation of NSAIDs.