Premium Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro‐oesophageal reflux disease – comparator study of esomeprazole, lansoprazole and pantoprazole
Morgan D.,
Pandolfino J.,
Katz P. O.,
Goldstein J. L.,
Barker P. N.,
Illueca M.
Publication year2010
Publication title
alimentary pharmacology and therapeutics
Resource typeJournals
Aliment Pharmacol Ther 2010; 32: 200–208 Summary Background  Hispanic‐Americans are a rapidly growing population in the United States, yet gastro‐oesophageal reflux disease (GERD) is not well studied in this population. Aim  To compare the efficacy of esomeprazole, lansoprazole and pantoprazole in suppressing gastric acid, including the area of the ‘acid pocket,’ in Hispanics with GERD. Methods  In this open‐label, 3‐way crossover study, 83 Hispanics with symptomatic GERD were randomized to 1 of 6 possible treatment sequences of three 5–7‐day dosing periods with esomeprazole 40 mg, lansoprazole 30 mg and pantoprazole 40 mg daily separated by 10–17‐day washout periods. Intragastric pH was measured for 24 h using dual probes with a distal and proximal (area of the ‘acid pocket’) electrode. Results  Esomeprazole suppressed intragastric acid (pH >4.0) significantly longer over 24 h (primary end point) compared with lansoprazole and pantoprazole ( P  <   0.0001), and proximal gastric acid (pH >4.0) significantly longer over 24 h compared with lansoprazole ( P  <   0.05) and pantoprazole ( P  <   0.0001). Conclusions  Esomeprazole was more effective than lansoprazole and pantoprazole in suppressing gastric acidity at both intragastric distal and proximal (area of the acid pocket) sites in Hispanics with GERD. Future studies are warranted to understand better the role of the acid pocket in GERD (Clinical trial numbers: D9612L00106; NCT00410592).
Subject(s)alternative medicine , crossover study , disease , environmental health , esomeprazole , gastric acid , gastroenterology , gerd , lansoprazole , medicine , omeprazole , pantoprazole , pathology , placebo , population , proton pump inhibitor , reflux , stomach
SCImago Journal Rank3.308

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