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Development and validation of a disease‐specific quality of life questionnaire for gastro‐oesophageal reflux disease: the GERD‐QOL questionnaire
Author(s) -
CHAN Y.,
CHING J. Y. L.,
CHEUNG C. M. Y.,
TSOI K. K. F.,
POLDERVERKIEL S.,
PANG S. H. Y.,
QUAN W. L.,
KEE K. M.,
CHAN F. K. L.,
SUNG J. J. Y.,
WU J. C. Y.
Publication year - 2010
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2009.04187.x
Subject(s) - medicine , gerd , reflux , gastro , disease , quality of life (healthcare) , gastroenterology , esophageal disease , esophagus , nursing
Aliment Pharmacol Ther 31 , 452–460 Summary Background A simple and meaningful health‐related quality of life (HRQoL) questionnaire for gastro‐oesophageal reflux disease (GERD) patients is lacking. Aim To develop and validate a disease‐specific HRQoL instrument (GERD‐QOL) for GERD patients. Methods An 18‐item questionnaire was generated to measure the impact of GERD on sleep, exercise, diet, need for medication, sex life, work, social activity and psychological well‐being. GERD patients were invited to complete the GERD‐QOL, a visual analogue scale (VAS) and a validated Chinese generic QoL (SF‐36) questionnaire before and after esomeprazole treatment. Factor analysis was performed for item selection and psychometric properties were measured. An English version was developed by a forward‐backward translation process. Results A final 16‐item GERD‐QOL questionnaire was developed. The items were grouped into four subscales (Daily activity, Treatment effect, Diet, and Psychological well‐being) after factor analysis. GERD‐QOL had good item‐internal consistency (Cronbach’s alpha: 0.64–0.88), high test‐retest reliability (intraclass correlation coefficient: 0.73–0.94, P < 0.001). Its subscale scores were correlated with SF‐36 and VAS, which demonstrated high construct validity ( P < 0.001). Discriminant validity was verified by correlating GERD‐QOL scores with symptom severity ( P < 0.001). Responsiveness after esomeprazole treatment was significant (paired‐ t ‐test P < 0.001). An English version of GERD‐QOL was developed. Conclusion The instrument, GERD‐QOL, is valid and reliable.