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Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging
Author(s) -
BABAEI A.,
BHARGAVA V.,
AALAM S.,
SCADENG M.,
MITTAL R. K.
Publication year - 2009
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2009.03947.x
Subject(s) - medicine , esomeprazole , meal , reflux , proton pump inhibitor , gastroenterology , gastric acid , magnetic resonance imaging , stomach , gastric content , proton magnetic resonance , volume (thermodynamics) , radiology , nuclear magnetic resonance , physics , disease , quantum mechanics
Summary Background Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro‐oesophageal reflux by decreasing acid secretion. Aim To determine the effect of PPI therapy on the gastric volume after a standard meal. Methods A total of nine healthy subjects were studied using magnetic resonance imaging, before and after a standard liquid meal mixed with a paramagnetic contrast to help demarcate the gastric region. Images were acquired for a total of 90 min after the meal. Studies were conducted before and following esomeprazole twice daily for 7 days. Images were analysed to determine the gastric liquid volume. Results Gastric volume, 15 min after the meal peaked to 611 ± 37 mL on the control day and 539 ± 30 mL following the PPI administration ( P < 0.001). Average gastric volume remained significantly lower (56 ± 9 mL, P < 0.05) on the PPI therapy from 5 to 75 min after the meal. Conclusions Proton pump inhibitor therapy causes a significant reduction in the gastric contents volume during first 75 min after the meal. In addition to increasing the gastric pH, PPI therapy may decrease the frequency of gastro‐oesophageal reflux by decreasing the volume of gastric contents.