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Administration of adalimumab in the treatment of Crohn’s disease of the ileal pouch
Author(s) -
SHEN B.,
REMZI F. H.,
LAVERY I. C.,
LOPEZ R.,
QUEENER E.,
SHEN L.,
GOLDBLUM J.,
FAZIO V. W.
Publication year - 2009
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2008.03920.x
Subject(s) - medicine , adalimumab , pouch , crohn's disease , regimen , pouchitis , gastroenterology , surgery , adverse effect , anastomosis , inflammatory bowel disease , disease
Summary Background Crohn’s disease (CD) of the pouch can develop in patients with ileal pouch‐anal anastomosis (IPAA). Scant data are available on the treatment of this disease entity. Aim To evaluate efficacy and safety of adalimumab in treating CD of the ileal pouch. Methods From June 2007 to June 2008, 17 IPAA patients with inflammatory ( n = 10), fibrostenotic ( n = 2) or fistulizing ( n = 5) CD of the pouch treated with adalimumab were evaluated. Inclusion criteria were CD of the pouch who failed medical therapy and were otherwise qualified for permanent pouch diversion or excision. All qualified patients received the standard dosing regimen of subcutaneous injection adalimumab (160 mg at week 0, 80 mg at week 1, and 40 mg every other week thereafter). Complete clinical response was defined as resolution of symptoms. Partial clinical response was defined as improvement in symptoms. Endoscopic inflammation before and after therapy was recorded, using the Pouchitis Disease Activity Index (PDAI) endoscopy subscores. Results The median age was 36 years with 12 patients (70.6%) being male. At 4 weeks, seven patients (41.2%) had a complete symptom response and 6 (35.3%) had a partial response. There was also a significant improvement in the PDAI endoscopy subscores at week 4 ( P < 0.05). At the last follow‐up (median of 8 weeks), eight patients (47.1%) had a complete symptom response and 4 (23.5%) had a partial response. Four patients (23.6%) developed adverse effects. Three patients (17.7%) eventually had pouch failure after failing to respond to adalimumab therapy. Conclusion Adalimumab appeared to be well‐tolerated and efficacious in treating CD of the pouch in this open‐labelled induction study.