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Adipokines and cytokines in non‐alcoholic fatty liver disease
Author(s) -
JARRAR M. H.,
BARANOVA A.,
COLLANTES R.,
RANARD B.,
STEPANOVA M.,
BENNETT C.,
FANG Y.,
ELARINY H.,
GOODMAN Z.,
CHANDHOKE V.,
YOUNOSSI Z. M.
Publication year - 2008
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2007.03586.x
Subject(s) - adipokine , adiponectin , medicine , steatohepatitis , resistin , fatty liver , endocrinology , steatosis , insulin resistance , obesity , disease
Summary Background Several adipocytokines have been implicated in the pathogenesis non‐alcoholic fatty liver disease (NAFLD). Aim To assess adipocytokines in NAFLD patients and controls. Methods A total of 95 patients (26 non‐alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non‐obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor‐α (TNF‐α), interleukin‐8 (IL‐8) and IL‐6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations. Results Serum TNF‐α and IL‐8 were higher in NAFLD patients when compared with both obese and non‐obese controls. Analysis involving all patients revealed a significant correlation between serum TNF‐α and IL‐8 ( P < 6.319e−08), and between IL‐6 and IL‐8 ( P < 5.271e−15). Homeostatic model assessment scores negatively correlated with adiponectin in NAFLD ( P < 0.0032). Serum visfatin was higher in all three obese groups than in non‐obese controls ( P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF‐α was associated with NAFLD ( P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL‐8 and adiponectin ( P < 0.05). Multivariate analysis indicated that TNF‐α was the only independent predictor of fibrosis in NASH ( P < 0.0004). Conclusion These findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.