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Four‐day continuous gastric pH monitoring following anti‐acid secretory drug administration: cross‐over test to assess the early effects
Author(s) -
SUZUKI T.,
YAMAGUCHI T.,
ODAKA T.,
KOBAYASHI M.,
SEZA A.,
KOUZU T.,
YOKOSUKA O.
Publication year - 2008
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2007.03545.x
Subject(s) - famotidine , lansoprazole , medicine , gastric acid , histamine h2 receptor , proton pump inhibitor , pharmacology , gastroenterology , omeprazole , stomach , antagonist , receptor
Summary Background There have been few reports that compare the effect of histamine H2‐receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) using continuous gastric pH monitoring for a long duration. Aim To assess the early effects of both drugs on gastric pH using a wireless pH monitoring system. Methods The test was conducted by a cross‐over test: 10 healthy male volunteers were administered famotidine 20 mg twice a day and lansoprazole 30 mg once a day. Monitoring of gastric pH over four consecutive days was performed using a unique method we have developed that is an elaboration of the Bravo system. Results The time to reach a pH level of 3 or more with famotidine was significantly shorter than that for lansoprazole. The pH3 holding time ratio of famotidine during the first 4 h of administration was significantly higher than that of lansoprazole. The pH3 holding time ratio on each day from day 1 to day 3 was significantly higher following lansoprazole administration compared with famotidine administration. Conclusions Famotidine was shown to act quickly in elevating gastric pH; however, lansoprazole was superior to famotidine in terms of its ability to elevate gastric pH for a long duration.