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Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn’s disease
Author(s) -
ROBLIN X.,
PHELIP J. M.,
GENEVOIS M.,
DUCROS V.,
BONAZ B.
Publication year - 2007
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2007.03260.x
Subject(s) - medicine , osteoporosis , crohn's disease , gastroenterology , vitamin d and neurology , bone disease , disease , surgery
Summary Background A high prevalence of osteoporosis is observed in Crohn’s disease. Recent data have shown that homocysteinaemia is an important risk factor in low‐bone mineralization and fracture. Aim To look for an association between homocysteinaemia and low‐bone mineralization in Crohn’s disease patients. Patients and methods Ninety‐two consecutive patients (sex ratio M/F 0.87; mean age: 36.6 ± 13.2 years) were recruited between 2003 and 2005. Bone densitometry was performed on inclusion. The following parameters were analysed: age, sex, Crohn’s Disease Activity Index, duration and extent of Crohn’s disease, smoking status, corticosteroid treatment, immunosuppressive drugs, plasma homocysteine, folate and vitamin B12 concentration. Results The prevalence of a high homocysteine level (>15 µmol/L) was 60%. Osteoporosis and low‐bone mineralization observed in 26 (28%), and 60 (65%) patients, respectively. On a multivariate analysis, associated factors for osteoporosis and low‐bone mineralization were respectively: hyperhomocysteinaemia (OR: 61.4; CI: 95: 23–250; P < 0.001), and ileal Crohn’s disease [OR: 13.8; CI: 95: 2.5–150; P = 0.036] for osteoporosis and hyperhomocysteinaemia [OR: 63.7; CI: 95: 8.5–250; P < 0.001] and disease duration of at least 5 years [OR: 11.4; CI: 95: 1.31–99; P = 0.039] for low‐bone mineralization. Results were similar whichever site osteoporosis was detected. Conclusion Hyperhomocysteinaemia was observed in 60% of our Crohn’s disease patients and was strongly associated with low‐bone mineralization and osteoporosis (OR: 61.4).