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Predictors of reduced health‐related quality of life in adults with coeliac disease
Author(s) -
HÄUSER W.,
STALLMACH A.,
CASPARY W. F.,
STEIN J.
Publication year - 2007
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.03227.x
Subject(s) - medicine , coeliac disease , quality of life (healthcare) , anxiety , depression (economics) , mental health , logistic regression , disease , physical therapy , psychiatry , nursing , economics , macroeconomics
Summary Background Data available on predictors of reduced health‐related quality of life in coeliac disease are not consistent. Aim To test predictors of reduced health‐related quality of life, described in the literature, by a multivariate approach. Methods 1000 adult coeliacs of the German Coeliac Society completed a medical and a sociodemographic questionnaire, the Short‐Form Health Survey (SF‐36), the Coeliac Disease Questionnaire and the Hospital Anxiety and Depression Scale within a postal survey. Predictors of reduced health‐related quality of life were tested for by logistic regression analysis. Results Physical comorbidities ( β = −0.41; OR = 0.66, P < 0.001) and mental disorder ( β = 0.88; OR = 2.4, P = 0.03) were associated with a reduced physical summary score of the SF‐36. Mental disorder ( β = 2.5; OR = 11.9, P < 0.001), physical comorbidities ( β = −0.26; OR = 0.77, P = 0.004) and younger age at diagnosis ( β = −0.10; OR = 0.91, P = 0.05) predicted a reduced mental summary score of the SF‐36. Mental disorder ( β = 0.90; OR = 2.5, P = 0.03), non‐compliance with gluten‐free diet ( β = 0.44; OR = 1.6, P = 0.009), active medical comorbidities ( β = −0.28; OR = 0.76, P = 0.007) and dissatisfaction with doctor–patient communication ( β = 0.55; OR = 1.7, P = 0.03) were associated with reduced Coeliac Disease Questionnaire scores. Conclusions Reduced health‐related quality of life in coeliac disease is associated not only with physical and mental comorbidities, but also with non‐compliance with gluten‐free diet and dissatisfaction with doctor–patient communication.