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Screening for liver disease using non‐invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia
Author(s) -
RATZIU V.,
GIRAL P.,
MUNTEANU M.,
MESSOUS D.,
MERCADIER A.,
BERNARD M.,
MORRA R.,
IMBERTBISMUT F.,
BRUCKERT E.,
POYNARD T.
Publication year - 2007
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.03182.x
Subject(s) - medicine , steatohepatitis , gastroenterology , metabolic syndrome , fatty liver , liver biopsy , cirrhosis , steatosis , insulin resistance , liver disease , cohort , population , disease , biopsy , insulin , obesity , environmental health
Summary Background Mortality related to complications of cirrhosis is increasing in patients with insulin‐resistance factors. Hyperlipidaemic patients have multiple risk factors of insulin resistance. It is impossible to perform liver biopsy in such a large number of hyperlipidaemic patients to identify patients with advanced liver fibrosis or with steatohepatitis (non‐alcoholic steatohepatitis, NASH). Aims To use the non‐invasive biomarkers, FibroTest (FT), SteatoTest and NashTest, and to assess the prevalence of advanced liver disease in a large population of hyperlipidaemic patients. Methods A consecutive cohort of hyperlipidaemic patients was followed prospectively in a lipid centre and the sera were analysed retrospectively. Results A total of 2834 subjects were included: 1909 hyperlipidaemic patients and 925 blood donors (BD). Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic patients vs. 0/925 BD (0%) ( P < 0.0001); advanced steatosis in 569/1893 hyperlipidaemic patients (30.1%) vs. 8/164 (4.9%) BD ( P < 0.0001) and NASH in 132/1893 (7%) vs. 0/164 (0%), respectively ( P < 0.0001). There was a highly significant and linear association between the number of metabolic syndrome factors and liver disease prevalence – the highest being for type 2 diabetics: advanced steatosis 66%, NASH 24% and advanced fibrosis 6%. Conclusions The prevalence of fibrosis, steatosis and NASH in hyperlipidaemic patients appears to be high (3%, 30% and 7%, respectively). Biomarkers could be useful for screening of advanced fibrosis and NASH in patients with several metabolic syndrome factors, to prevent liver mortality.