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An in vitro comparison of different providers to deliver four proton pump inhibitor products through a feeding tube
Author(s) -
DEVLIN J. W.,
BAKSHI A.,
BUNGAY K.,
OLSEN K. M.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.03169.x
Subject(s) - lansoprazole , omeprazole , esomeprazole , proton pump inhibitor , medicine , pharmacology , oral administration
Summary Background It is unclear how delivery through a feeding tube compares between esomeprazole in water, lansoprazole oral disintegrating tablet in water, omeprazole/NaHCO 3 in water and simplified lansoprazole suspension. Aim This in vitro study compared delivery through a narrow calibre (8F) feeding tube among four proton pump inhibitors when given by skilled [nurse; ( n = 8)] or unskilled [lay; ( n = 8)] providers. Methods Following standard instruction, subjects were observed delivering each proton pump inhibitor in a sequential, but random, fashion to evaluate administration quality and time. Delivery was quantified using high‐performance liquid chromatography methods and subject preferences were evaluated. Results Delivery (%), similar between lansoprazole oral disintegrating tablet (95.7 ± 3.2) and omeprazole/NaHCO 3 (96.1 ± 3.0), was both greater for lansoprazole oral disintegrating tablet than esomeprazole in water (88.9 ± 8.6; P = 0.006) or simplified lansoprazole suspension (86.1 ± 9.5; P = 0.0001) and omeprazole/NaHCO 3 than esomeprazole in water ( P = 0.004) or simplified lansoprazole suspension ( P < 0.001), and was not affected by prior subject experience. Quality was higher with both omeprazole/NaHCO 3 and lansoprazole oral disintegrating tablet than simplified lansoprazole suspension. Administration was quicker for lansoprazole oral disintegrating tablet than esomeprazole in water. Subjects preferred lansoprazole oral disintegrating tablet and omeprazole/NaHCO 3 . Conclusions When given through an in vitro feeding tube, omeprazole/NaHCO 3 and lansoprazole oral disintegrating tablet lead to greater drug delivery, improved administration quality and higher user satisfaction, than either esomeprazole in water or simplified lansoprazole suspension.