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Lactobacillus reuteri therapy to reduce side‐effects during anti‐ Helicobacter pylori treatment in children: a randomized placebo controlled trial
Author(s) -
LIONETTI E.,
MINIELLO V. L.,
CASTELLANETA S. P.,
MAGISTÁ A. M.,
DE CANIO A.,
MAUROGIOVANNI G.,
IERARDI E.,
CAVALLO L.,
FRANCAVILLA R.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.03145.x
Subject(s) - medicine , lactobacillus reuteri , placebo , helicobacter pylori , omeprazole , gastroenterology , urea breath test , tinidazole , randomized controlled trial , antibiotics , breath test , clarithromycin , regimen , amoxicillin , probiotic , helicobacter pylori infection , microbiology and biotechnology , metronidazole , genetics , alternative medicine , pathology , bacteria , biology
Summary Background Helicobacter pylori eradication fails in about 25–30% of children, particularly because of the occurrence of resistance to antibiotics and side‐effects. Aim To determine whether adding the Lactobacillus reuteri to an anti‐ H. pylori regimen could help to prevent or minimize the gastrointestinal side‐effects burden in children. Methods Forty H. pylori ‐positive children (21 males; median age: 12.3 years) were consecutively treated with 10‐day sequential therapy [omeprazole + amoxycillin for 5 days, and omeprazole + clarithromycin + tinidazole for other 5 days] and blindly randomized to receive either L. reuteri ATCC 55730 (10 8 CFU) or placebo. All children completed the Gastrointestinal Symptom Rating Scale (GSRS) at entry, during and after treatment. H. pylori status was assessed after 8 weeks by 13 C‐urea breath test. Results Overall, in all probiotic supplemented children when compared with those receiving placebo there was a significant reduction of GSRS score during eradication therapy (4.1 ± 2 vs. 6.2 ± 3; P < 0.01) and at the end of follow‐up (3.2 ± 2 vs. 5.8 ± 3.4; P < 0.009). Overall, children receiving L. reuteri report less symptoms than those receiving placebo. Conclusion L. reuteri is capable of reducing frequency and intensity of antibiotic‐associated side‐effects during eradication therapy for H. pylori .