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Review article: management of hepatic disease following haematopoietic cell transplant
Author(s) -
McDONALD G. B.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.03001.x
Subject(s) - medicine , disease , haematopoiesis , gastroenterology , immune system , stem cell , immunology , genetics , biology
Summary Hepatic diseases are common complications of haematopoietic cell transplant. The causes are multiple: myeloablative conditioning regimens may cause sinusoidal injury; acute and chronic graft‐versus‐host disease lead to damaged hepatocytes and small bile ducts; microcrystalline deposits in the gall bladder can cause biliary symptoms; drug‐induced liver injury is common; and the liver may be infected by viruses and fungi during the period of severe immune suppression that follows transplant. Pre‐transplant evaluation and prevention of liver injury are often more useful than treatment of deeply jaundiced patients in improving transplant outcomes. This review covers pre‐transplant evaluation, common hepatobiliary problems in the six months following transplant, and hepatic problems in long‐term survivors.