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Effect of oral clarithromycin on gall‐bladder motility in normal subjects and those with gall‐stones
Author(s) -
SENGUPTA S.,
MODAK P.,
McCAULEY N.,
O'DONNELL L. J. D.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02962.x
Subject(s) - postprandial , medicine , clarithromycin , gall , erythromycin , placebo , prokinetic agent , gastroenterology , hepatology , crossover study , helicobacter pylori , antibiotics , pathology , biology , botany , alternative medicine , insulin , microbiology and biotechnology
Summary Background Motilin receptor stimulation with erythromycin has been shown to have a prokinetic effect on gall‐bladder motility in human beings. Aim To find out whether oral clarithromycin has similar prokinetic activity to erythromycin on fasting and postprandial gall‐bladder emptying in normal humans and those with gall‐stone disease. Methods In a blinded two‐way crossover study clarithromycin 500 mg and a placebo were administered to 10 normal subjects and 10 subjects with gall‐stone disease. Gall‐bladder volumes were assessed in the fasting and postprandial state. Results Fasting volumes were significantly less following clarithromycin administration in both normal subjects and subjects with gall‐stones compared with placebo (12.1 ± 1.8 mL vs. 17.8 ± 2.0 mL, P < 0.05 and 16.7 ± 2 mL vs. 26.8 ± 7.2 mL, P < 0.02, mean ± S.E.M). Postprandial volumes were also significantly less following clarithromycin administration. Ejection fraction significantly increased following clarithromycin in both normal subjects (66 ± 5.8% vs. 37 ± 5.9%, P = 0.02) and subjects with gall‐stones (45 ± 3.2 vs. 20 ± 1.6%, P < 0.02). Conclusion Clarithromycin enhances both fasting and postprandial gall‐bladder contraction in normal humans and also in those with gall‐stone disease.