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Coexistence between colorectal cancer/adenoma and coronary artery disease: results from 1382 patients
Author(s) -
CHAN A. O. O.,
LAM K. F.,
TONG T.,
SIU D. C. W.,
JIM M. H.,
HUI W. M.,
LAI K. C.,
YUEN M. F.,
LAM S. K.,
WONG B. C. Y.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02958.x
Subject(s) - medicine , coronary artery disease , colorectal cancer , logistic regression , family history , gastroenterology , cardiology , disease , cancer
Summary Background Common risk factors exist in colorectal neoplasia (cancer or adenoma) and coronary artery disease. Aim To investigate in a retrospective study if there is coexistence of the two events in patients ≥50 years. Methods Computer data on colonoscopies performed on symptomatic patients, the corresponding medical record and colonic histology in 1997–2000 were retrieved. History of coronary artery disease was recorded. To adjust for the factors of age and sex, bivariate logistic regression analysis was used to test for coexistence. Results 1382 patients were recruited. Colorectal neoplasia and history of coronary artery disease were present in 27% (373) and 12% (167) of patients, respectively. The mean age of patients was older in colorectal neoplasia+ (75 ± 11 vs. 69 ± 13 years, P < 0.0001) and in coronary artery disease+ (79 ± 9 vs. 69 ± 12 years, P < 0.0001) patients. Male was the predominant sex in colorectal neoplasia+: 33% vs. 22% ( P < 0.0001), but not in coronary artery disease+ ( P = 0.29). Colorectal neoplasia+ patients were more likely to have coronary artery disease+ [21.2% (79/373) vs. 8.8% (89/1098) ( P < 0.0001)]. Bivariate logistic regression analysis showed strong association between the two events (OR: 2.12, 95% CI: 1.5, 3.0). Conclusion There is strong coexistence of colorectal neoplasia and coronary artery disease, probably due to exposure to common risk factors.