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The 5‐HT 4 antagonist R216073 does not affect gastric motor and sensory function in patients with functional dyspepsia
Author(s) -
VAN LELYVELD N.,
TER LINDE J.,
BARON A.,
MUNDT M.,
WAJS E.,
SAMSOM M.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02951.x
Subject(s) - medicine , serotonin , crossover study , antagonist , placebo , gastroenterology , 5 ht receptor , stomach , receptor antagonist , endocrinology , receptor , anesthesia , pathology , alternative medicine
Summary Background Serotonin and the 5‐HT 4 receptor play an important role in gastrointestinal motor and sensory functions. While 5‐HT 4 agonists are known for their prokinetics properties, the effect of 5‐HT 4 antagonists on upper gastrointestinal functions is largely unknown. Aim To assess the effect of a 5‐HT 4 receptor antagonist (R216073) on gastric relaxation and visceral sensitivity in patients with functional dyspepsia. Secondly, the influence of a functional polymorphism in the gene encoding the serotonin transport protein on drug response was determined. Methods A double‐blind, randomized, placebo‐controlled, two‐period crossover study was performed in 20 functional dyspepsia patients. The effect of a single dose of 2000 mg R216073 on gastric relaxation and sensitivity was tested using three‐dimensional ultrasonography and a nutrient drinktest. Results R216073 did not affect partial gastric volumes or upper abdominal sensations scored during three‐dimensional ultrasonography ( P > 0.05). The maximum tolerated volume or upper abdominal sensations induced by the drinktest were not affected by R216073 ( P > 0.05). The serotonin transport protein promoter polymorphism was not associated with any of the end‐points of the study. Conclusions A single dose of R216073 had no effect on fundic relaxation, drinking capacity, or upper abdominal symptoms in patients with functional dyspepsia.