Premium
Serum bilirubin and colorectal cancer risk: a population‐based cohort study
Author(s) -
IOANNOU G. N.,
LIOU I. W.,
WEISS N. S.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02939.x
Subject(s) - medicine , colorectal cancer , incidence (geometry) , quartile , bilirubin , population , cohort , body mass index , national health and nutrition examination survey , cohort study , gastroenterology , cancer , confidence interval , environmental health , physics , optics
Summary Background Bilirubin has antioxidant properties and has been postulated to protect against the development of malignancies. Aim To investigate whether baseline serum bilirubin concentration predicts the incidence of colorectal cancer in a nationally representative sample of the US population. Methods Participants of the first National Health and Nutrition Examination Survey were divided into four groups based on quartiles of baseline serum bilirubin concentration in mg/dL: <0.38 ( n = 1410), 0.38 to <0.5 ( n = 1287), 0.5 to <0.6 ( n = 1048) and ≥0.6 ( n = 1742). The incidence of colorectal cancer during the following 20 years was determined from hospitalization records and death certificates. Results 110 cases of colorectal cancer‐related death or hospitalization were identified among 5487 participants during 88 339 person‐years of follow‐up (12 per 10 000 person‐years). There was no association between baseline serum bilirubin concentration and the incidence of colorectal cancer either in unadjusted analyses or after adjusting for age, gender, ethnicity, smoking, body mass index, alcohol consumption and educational attainment. Conclusions Baseline serum bilirubin concentration did not predict the subsequent incidence of colorectal cancer in this population‐based cohort study.