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White wine and beer induce gastro‐oesophageal reflux in patients with reflux disease
Author(s) -
PEHL C.,
WENDL B.,
PFEIFFER A.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02922.x
Subject(s) - reflux , medicine , gastro , white wine , gastroenterology , disease , wine , white (mutation) , food science , chemistry , biochemistry , gene
Summary Background An induction of gastro‐oesophageal reflux has been reported after ingestion of alcoholic beverages in healthy volunteers. However, it is unknown whether reflux in gastro‐oesophageal reflux disease patients will be enhanced by the ingestion of alcoholic beverages. Aim To investigate the effects of wine and beer on postprandial reflux in reflux patients. Methods Twenty‐five patients (reflux oesophagitis 15, non‐erosive reflux disease 10; 18 men and seven women) drank 300‐mL white wine ( n = 17), 500‐mL beer ( n = 8), or identical amounts of tap water (controls) together with a standardized meal in a randomized order. pH‐measurement was carried out during three postprandial hours by pH‐metry and the percentage of time pH < 4 was calculated. Results Both alcoholic beverages increased reflux compared with water [wine 23% (median), water 12%, P < 0.01; beer 25%, water 11%, P < 0.05]. Between wine and beer, no difference in reflux induction was obtained. The reflux induction was seen in patients with (23%, P < 0.01) and without reflux oesophagitis (22%, P < 0.05) and in both sexes (women 23%, men 25%, P < 0.05 each). Conclusions Ingestion of commonly consumed alcoholic beverages such as wine and beer induces gastro‐oesophageal reflux in gastro‐oesophageal reflux disease patients. Therefore, these patients should be advised to avoid the intake of large amounts (≥300 mL) of these beverages.