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Lamivudine monotherapy in HBeAg‐negative chronic hepatitis B: prediction of response‐breakthrough and long‐term clinical outcome
Author(s) -
MANOLAKOPOULOS S.,
BETHANIS S.,
ELEFSINIOTIS J.,
KARATAPANIS S.,
TRIANTOS C.,
SOURVINOS G.,
TOULOUMI G.,
ECONOMOU M.,
VLACHOGIANNAKOS J.,
SPANDIDOS D.,
AVGERINOS A.,
TZOURMAKLIOTIS D.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02806.x
Subject(s) - lamivudine , medicine , gastroenterology , cirrhosis , hbeag , hepatitis b , hepatitis b virus , liver biopsy , chronic hepatitis , virus , immunology , biopsy , hbsag
Summary Background Factors that predict response and breakthrough phenomenon to lamivudine monotherapy in patients with HBeAg‐negative chronic hepatitis B have not been well defined. Aim To determine pre‐treatment and on treatment variables that predict initial response and breakthrough in patients with HBeAg‐negative chronic hepatitis B receiving long‐term lamivudine. Methods Seventy‐nine patients, with chronic HBeAg‐negative hepatitis B, who received lamivudine for a median of 31 months were included in the study. Results Initial virologic and biochemical response was observed in 73 (92%) and 70 (89%) patients, respectively, while 34 (47%) and 15 (21%) patients developed virological and biochemical breakthrough, respectively. High levels of necroinflammation in liver biopsy were associated with a higher probability of initial virological and biochemical response. Patients with pre‐treatment serum hepatitis B virus DNA concentrations of more than 10 6 copies/mL were three times more likely to develop virologic breakthrough. Two patients died, one with baseline cirrhosis because of liver failure during biochemical breakthrough while the second death was liver and treatment unrelated. Conclusions In HBeAg‐negative chronic hepatitis B, initial response to lamivudine therapy is associated with necroinflammation, while baseline serum hepatitis B virus DNA exceeding 10 6 copies/mL is a strong predictor for breakthrough because of drug‐resistant mutations. Severe complications are uncommon and are associated with biochemical breakthrough and pre‐existing cirrhosis.