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Validation of a symptom diary for patients with gastro‐oesophageal reflux disease
Author(s) -
PUHAN M. A.,
GUYATT G. H.,
ARMSTRONG D.,
WIKLUND I.,
FALLONE C. A.,
HEELSANSDELL D.,
DEGL'INNOCENTI A.,
ZANTEN S. J. O. VELDHUYZEN,
TANSER L.,
BARKUN A. N.,
CHIBA N.,
AUSTIN P.,
ELDIKA S.,
SCHÜNEMANN H. J.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02775.x
Subject(s) - heartburn , medicine , antacid , reflux , esomeprazole , gastro , quality of life (healthcare) , disease , ambulatory , esophageal disease , gastroenterology , physical therapy , esophagus , nursing
Summary Background Symptom diaries are potentially attractive but, because of concerns about patient compliance, they have had limited use in clinical trials. We assessed the validity and responsiveness of a symptom diary for patients with gastro‐oesophageal reflux disease. Methods We included 215 patients with gastro‐oesophageal reflux disease after starting treatment for 4 weeks with 40 mg esomeprazole once daily. Patients recorded whether they experienced night‐time heartburn (yes/no), the severity of daytime heartburn on a scale from 1 (no heartburn) to 4 (severe heartburn) and their antacid use. Patients also completed a number of disease‐specific and preference‐based Health‐related Quality of Life questionnaires at baseline and follow‐up. Results Consistent with a priori predictions, daytime heartburn showed moderate to strong correlations with the Quality of Life in Reflux and Dyspepsia questionnaire (0.36–0.67) and four scales of symptom severity (0.36–0.70) for baseline, follow‐up and change scores, but low correlations with the Standard Gamble. Responsiveness of the daytime heartburn item was excellent with a mean change from baseline to follow‐up of −1.3 (95% CI −1.4 to −1.1) and a standardized response mean of 1.33 while responsiveness of the daily antacid use item was moderate (mean change scores −1.8 tablets taken, 95% CI −2.3 to −1.3 and standardized response mean of 0.64). Conclusions The excellent psychometric properties of this simple gastro‐oesophageal reflux disease diary make it an attractive measure for future trials.