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Lansoprazole, levofloxacin and amoxicillin triple therapy vs. quadruple therapy as second‐line treatment of resistant Helicobacter pylori infection
Author(s) -
WONG W. M.,
GU Q.,
CHU K.M.,
YEE Y. K.,
FUNG F. M. Y.,
TONG T. S. M.,
CHAN A. O. O.,
LAI K. C.,
CHAN C. K.,
WONG B. C. Y.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02764.x
Subject(s) - levofloxacin , lansoprazole , amoxicillin , metronidazole , clarithromycin , medicine , helicobacter pylori , gastroenterology , antibacterial agent , breath test , antibiotics , microbiology and biotechnology , biology
Summary Aim To test the efficacy of levofloxacin‐based second‐line therapy for resistant Helicobacter pylori infection. Methods One hundred and six patients who failed H. pylori eradication were randomized to receive (i) lansoprazole 30 mg, amoxicillin 1 g, levofloxacin 500 mg, all given twice daily for 7 days (LAL); or (ii) lansoprazole 30 mg twice daily, metronidazole 400 mg thrice daily, bismuth subcitrate 120 mg and tetracycline 500 mg four times daily for 7 days (quadruple). Post‐treatment H. pylori status was determined by 13 C‐urea breath test. Results Intention‐to‐treat and per‐protocol H. pylori eradication rates were 57/60% for the LAL group and 71/76% for the quadruple group respectively. Metronidazole, clarithromycin, amoxicillin and levofloxacin resistance were found in 76%, 71%, 0% and 18% of patients, respectively. Levofloxacin resistance led to treatment failure in the LAL group. For patients with dual resistance to metronidazole and clarithromycin, the eradication rates were 79% in the LAL group (levofloxacin‐sensitive) and 65% in the quadruple group ( P = 0.34). Conclusion Lansoprazole, amoxicillin plus levofloxacin second‐line therapy is comparable with quadruple therapy in efficacy. Subjects, especially those with dual resistance to metronidazole and clarithromycin, may consider levofloxacin‐based therapy for levofloxacin‐sensitive strains.