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Peroxisome proliferator‐activated receptor‐gamma Pro12Ala polymorphism, Helicobacter pylori infection and non‐cardia gastric carcinoma in Chinese
Author(s) -
LIAO S.Y.,
ZENG Z.R.,
LEUNG W. K.,
ZHOU S.Z.,
CHEN B.,
SUNG J. J. Y.,
HU P.J.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.02739.x
Subject(s) - peroxisome proliferator activated receptor , helicobacter pylori , cancer , medicine , gastroenterology , allele , peroxisome proliferator activated receptor alpha , peroxisome proliferator activated receptor gamma , receptor , biology , cancer research , endocrinology , immunology , gene , genetics , nuclear receptor , transcription factor
Summary Background Peroxisome proliferator‐activated receptor γ inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. Aim To study the association between peroxisome proliferator‐activated receptor γ gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese. Methods One hundred and four consecutive patients with non‐cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator‐activated receptor γ Pro12Ala polymorphism was analysed by polymerase chain reaction‐restriction fragment length polymorphism. Results The frequency of peroxisome proliferator‐activated receptor γ G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1–5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6–5.7), the combination of peroxisome proliferator‐activated receptor γ G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2–50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori ‐negative subjects. Conclusion Our study suggests the potential association between peroxisome proliferator‐activated receptor γ polymorphism and H. pylori infection in the development of non‐cardia gastric cancer.